| Place | Time | Name (Yr) | School | City | State |
| 1 | *:48.34* | Missy Franklin (11) | Regis Jesuit High School | Aurora | CO |
| * Note - Missy Franklin's :48.34 was altituded adjusted. Her official unadjusted time is | |||||
| :48.45 | |||||
| 2 | :48.61 | Jasmine Tosky (12) | Palo Alto High School | Palo Alto | CA |
| 3 | :48.67 | Kristen Vredeveld (11) | The Baylor School | Chattanooga | TN |
| 4 | :48.88 | Olivia Smoliga (11) | Glenbrook South High School | Glenview | IL |
| 5 | :48.98 | Rachael Acker (12) | Gunn High School | Palo Alto | CA |
| 6 | :49.01 | Meaghan Raab (10) | Hershey High School | Hershey | PA |
| 7 | :49.52 | Janet Hu (10) | Oakton High School | Vienna | VA |
| 8 | :49.53 | Julia Anderson (12) | Paschal High School | Fort Worth | TX |
| 9 | :49.54 | Lindsey Engel (10) | Crean Lutheran High School | Irvine | CA |
| 10 | :49.71 | Faith Johnson (12) | High Point Christian Academy | High Point | NC |
| 11 | :49.75 | Linnea Mack (11) | Pioneer High School | San Jose | CA |
| 12 | :49.79 | Kelsi Worrell (12) | Rancocas Valley Regional High School | Mount Holly | NJ |
| 13 | :49.91 | Lindsey McKnight (12) | American Heritage School | Plantation | FL |
| 14 | :49.94 | Samantha James (12) | New Trier High School | Winnetka | IL |
| 14 | :49.94 | Olivia Kabacinski (12) | Chesterton High School | Chesterton | IN |
| 14 | :49.94 | Caroline McTaggart (9 ) | The Holton Arms School | Bethesda | MD |
| 17 | :50.18 | Kaia Grobe (9 ) | Chanhassen High School | Chanhassen | MN |
| 18 | :50.19 | Madison White (11) | Carondelet High School | Concord | CA |
| 19 | :50.22 | Valerie Hull (10) | Westview High School | San Diego | CA |
| 20 | :50.27 | Zoe Mattingly (12) | Zionsville Community High School | Zionsville | IN |
| 21 | :50.29 | Emily Allen (9 ) | William A. Hough High School | Cornelius | NC |
| 21 | :50.29 | Anika Apostalon (11) | Albuquerque Academy | Albuquerque | NM |
| 23 | :50.31 | Alex Merritt (12) | Lincoln High School | Tallahassee | FL |
| 24 | :50.32 | Annelise Jongekrijg (12) | Lake Orion High School | Lake Orion | MI |
| 25 | :50.33 | Chase Kinney (11) | Jackson High School | Massillon | OH |
| 26 | :50.39 | Elizabeth McDonald (12) | Pomperaug High School | Southbury | CT |
| 27 | :50.44 | Catherine Galletti (12) | Trinity Preparatory School | Winter Park | FL |
| 28 | :50.45 | Catherine Ladd (10) | Willow Glen High School | San Jose | CA |
| 29 | :50.46 | Mallory Comerford (9 ) | Plainwell High School | Plainwell | MI |
| 30 | :50.47 | Meredith Oliver (12) | Robert E. Lee High School | Tyler | TX |
| 31 | :50.52 | Ally Hardesty (12) | Bearden High School | Knoxville | TN |
| 32 | :50.53 | Rachel Moore (12) | Andover High School | Andover | MA |
| 33 | :50.55 | Lauren Rhodes (10) | Charlotte Catholic High School | Charlotte | NC |
| 34 | :50.58 | Julia Ama (12) | Gunn High School | Palo Alto | CA |
| 35 | :50.61 | Sarah Gibson (11) | Ronald Reagan High School | San Antonio | TX |
| 36 | :50.62 | Anna Keane (10) | Meadowdale High School | Lynnwood | WA |
| 37 | :50.63 | Kaitlyn Albertoli (9 ) | JSerra Catholic High School | San Juan Capistrano | CA |
| 38 | :50.65 | Kina Zhou (11) | Niskayuna High School | Niskayuna | NY |
| 39 | :50.71 | Grace Long (9 ) | Upper Arlington High School | Upper Arlington | OH |
| 39 | :50.71 | Alexandra Rockett (10) | Wilson High School | West Lawn | PA |
| 41 | :50.74 | Breanna Robinson (9 ) | Wawesee High School | Syracuse | IN |
| 42 | :50.75 | Clara Baggett (9 ) | Mt. Vernon High School | Mt. Vernon | IN |
| 42 | :50.75 | Rachel Zilinskas (11) | Germantown Academy | Fort Washington | PA |
| 44 | :50.78 | Iris Brand (9 ) | Amador Valley High School | Pleasanton | CA |
| 44 | :50.78 | Cheyenne Low (11) | University High School | Irvine | CA |
| 46 | :50.79 | Reia Tong (12) | Walt Whitman High School | Bethesda | MD |
| 47 | :50.80 | Bonnie Brandon (12) | Cherry Creek High School | Greenwood Village | CO |
| 47 | :50.80 | Catherine DeLoof (9 ) | Grosse Pointe South High School | Grosse Pointe Farms | MI |
| 47 | :50.80 | Carly Reid (10) | Monta Vista High School | Cupertino | CA |
| 50 | :50.82 | Alysha Bush (11) | Newberg High School | Newberg | OR |
| 50 | :50.82 | Jenna Immormino (12) | Kent Place School | Summit | NJ |
| 52 | :50.83 | Alex Hubel (9 ) | Boulder City High School | Boulder City | NV |
| 53 | :50.92 | Kirsten Brand (11) | Amador Valley High School | Pleasanton | CA |
| 54 | :50.94 | Allison Brown (12) | San Ramon Valley High School | Danville | CA |
| 54 | :50.94 | Holly Morren (10) | Holland High School | Holland | MI |
| 56 | :50.95 | Savannah Miller (12) | Westlake High School | Westlake Village | CA |
| 57 | :50.97 | Sarah Koucheki (11) | Hawken School | Gates Mills | OH |
| 58 | :50.98 | Sammie Hashbarger (10) | McKinney High School | McKinney | TX |
| 59 | :50.99 | Rhianna Williams (11) | Fossil Ridge High School | Fort Collins | CO |
| 60 | :51.00 | Natilee Ruiz (12) | Othello High School | Othello | WA |
| 61 | :51.03 | Kristen Clarno (12) | Homestead High School | Cupertino | CA |
| 62 | :51.06 | Kelsey Gouge (12) | Brookwood High School | Snellville | GA |
| 62 | :51.06 | Michelle Turek (9 ) | Palm Harbor University High School | Palm Harbor | FL |
| 64 | :51.07 | Daniela Johnson (11) | Miami Palmetto Senior High School | Pinecrest | FL |
| 64 | :51.07 | Macie McNichols (10) | Gilmour Academy | Gates Mills | OH |
| 66 | :51.08 | Alyssa Ruffing (10) | Franklin Regional High School | Murrysville | PA |
| 67 | :51.11 | Ellie Morrissey (12) | Edison High School | Huntington Beach | CA |
| 68 | :51.13 | Olivia Morrell (11) | Volcano Vista High School | Albuquerque | NM |
| 68 | :51.13 | Megan Strickland (10) | Churchill High School | San Antonio | TX |
| 70 | :51.14 | Katie Grover (10) | Milton High School | Milton | GA |
| 70 | :51.14 | Alexandra Marshall (11) | Ronald Wilson Reagan High School | Pfafftown | NC |
| 72 | :51.15 | Annie Tamblyn (12) | Ann Arbor Huron High School | Ann Arbor | MI |
| 73 | :51.16 | Rebecca Baxley (11) | Analy High School | Sebastopol | CA |
| 73 | :51.16 | Monica Bottelberghe (10) | Columbia River High School | Vancouver | WA |
| 73 | :51.16 | Isabel Wyer (10) | Minnetonka High School | Minnetonka | MN |
| 76 | :51.17 | Maggie McCord (12) | Canyon Del Oro High School | Tucson | AZ |
| 76 | :51.17 | Maylin Meisenheimer (12) | King High School | Corpus Christi | TX |
| 78 | :51.18 | Sarah Love (11) | duPont Manual High School | Louisville | KY |
| 78 | :51.18 | Megan Lydzinski (12) | Montgomery High School | Skillman | NJ |
| 78 | :51.18 | Remedy Rule (9 ) | Western Albemarle High School | Crozet | VA |
| 81 | :51.19 | Nikki Larson (12) | Edina High School | Edina | MN |
| 82 | :51.20 | Temarie Tomley (10) | Ursuline Academy | Cincinnati | OH |
| 83 | :51.21 | Allie Pennetti (12) | North Allegheny High School | Wexford | PA |
| 83 | :51.21 | Gillian St. John (9 ) | Albuquerque Academy | Albuquerque | NM |
| 85 | :51.23 | Emily Stang (12) | Parkland High School | Allentown | PA |
| 86 | :51.25 | Riki Bonnema (12) | Olympia High School | Orlando | FL |
| 86 | :51.25 | Madison Martin (11) | Pickerington High School Central | Pickerington | OH |
| 88 | :51.26 | Mackenzie Franklin (11) | Westlake High School | Austin | TX |
| 89 | :51.27 | Danielle Freeman (11) | Hudsonville High School | Hudsonville | MI |
| 90 | :51.28 | Rylee Klomp (11) | Mercyhurst Preparatory School | Erie | PA |
| 91 | :51.30 | Lauren Hall (11) | Countryside High School | Clearwater | FL |
| 91 | :51.30 | Madelyn Veith (10) | Hershey High School | Hershey | PA |
| 93 | :51.31 | Meagan Dollard (10) | Germantown Academy | Fort Washington | PA |
| 94 | :51.32 | Sarah Hitchens (11) | Villa Maria Academy | Malvern | PA |
| 95 | :51.33 | Morgan Karetnick (12) | Greenwich High School | Greenwich | CT |
| 95 | :51.33 | Kristin Malone (10) | Shorewood High School | Shorewood | WI |
| 97 | :51.35 | Haley Rose Love (11) | Heritage High School | Brentwood | CA |
| 97 | :51.35 | Valerie Yoshimura (9 ) | Baldwin School | Bryn Mawr | PA |
| 99 | :51.36 | Eryn Eddy (9 ) | Thompson Valley High School | Loveland | CO |
| 100 | :51.37 | Courtney Caldwell (9 ) | Lawrence Free State High School | Lawrence | KS |