| Place | Time | Swimmer (Yr) | School | City | State |
| 1 | :47.82 | Abbey Weitzeil (11) | Saugus High School | Saugus | CA |
| 2 | :48.67 | Jasmine K Mau (12) | Punahou School | Honolulu | HI |
| 3 | :48.93 | Amy Bilquist (11) | Carmel High School | Carmel | IN |
| 4 | :49.00 | Lindsey Engel (12) | Crean Lutheran High School | Irvine | CA |
| 5 | :49.68 | Emily Allen (11) | William A. Hough High School | Cornelius | NC |
| 6 | :49.69 | Alex Cleveland (12) | Zionsville Community High School | Zionsville | IN |
| 6 | :49.69 | Valerie Hull (12) | Westview High School | San Diego | CA |
| 8 | :49.73 | Hannah Stevens (12) | Lexington High School | Lexington | OH |
| 9 | :49.78 | Caitlin Cooper (12) | Woodward Academy | College Park | GA |
| 10 | :49.81 | Annie Ochitwa (11) | Thunderridge High School | Highlands Ranch | CO |
| 11 | :49.82 | Kaitlyn Albertoli (11) | Jserra Catholic High School | San Juan Capistrano | CA |
| 11 | :49.82 | Ella Eastin (11) | Crean Lutheran High School | Irvine | CA |
| 11 | :49.82 | Amy Lubawy (12) | Bishop Gorman High School | Las Vegas | NV |
| 14 | :49.86 | Abby Jagdfeld (12) | Waukesha South High School | Waukesha | WI |
| 14 | :49.86 | Lexie Lupton (11) | Kingwood High School | Kingwood | TX |
| 16 | :49.87 | Mollie Pulte (11) | Marian High School | Bloomfield Hills | MI |
| 16 | :49.87 | Meaghan Raab (12) | Hershey High School | Hershey | PA |
| 18 | :49.90 | Katie Grover (12) | Milton High School | Milton | GA |
| 19 | :49.93 | GraceAnne Long (11) | Upper Arlington High School | Upper Arlington | OH |
| 20 | :49.96 | Jamie Stone (9 ) | Centennial High School | Gresham | OR |
| 21 | :50.04 | Abbie Dolan (10) | Visitation High School | Mendota Heights | MN |
| 22 | :50.10 | Rachel Hayden (12) | North Central High School | Indianapolis | IN |
| 23 | :50.12 | Ally Howe (12) | Sacred Heart Preparatory | Atherton | CA |
| 23 | :50.12 | Gabby Sims (12) | Downers Grove North High School | Downers Grove | IL |
| 25 | :50.16 | Erin Falconer (11) | Mundelein High School | Mundelein | IL |
| 26 | :50.17 | Emma Chard (12) | Henry Foss High School | Tacoma | WA |
| 27 | :50.19 | Jerrica Li (10) | Longmeadow High School | Longmeadow | MA |
| 28 | :50.21 | Caroline McTaggart (11) | The Holton Arms School | Bethesda | MD |
| 29 | :50.23 | Katie Portz (10) | Skyline High School | Ann Arbor | MI |
| 30 | :50.26 | Catherine Ladd (12) | Willow Glen High School | San Jose | CA |
| 31 | :50.29 | Iris Brand (11) | Amador Valley High School | Pleasanton | CA |
| 32 | :50.30 | Macie McNichols (12) | Gilmour Academy | Gates Mills | OH |
| 33 | :50.32 | Alexandra Buscher (11) | Memorial High School | Houston | TX |
| 34 | :50.34 | Lauren E. Heller (10) | Walsh Jesuit High School | Cuyahoga Falls | OH |
| 34 | :50.34 | Laurem Moden (11) | Legend High School | Parker | CO |
| 36 | :50.35 | Kirsten Jacobsen (10) | Barrington High School | Barrington | IL |
| 37 | :50.37 | Hannah Baker (10) | Robinson Secondary School | Fairfax | VA |
| 38 | :50.39 | Ashley Volpenhein (9 ) | Mason High School | Mason | OH |
| 39 | :50.40 | Alexandria Hubel (11) | Boulder City High School | Boulder City | NV |
| 40 | :50.42 | Marta Ciesla (9 ) | Pine Crest School | Fort Lauderdale | FL |
| 41 | :50.44 | Carly Reid (12) | Monta Vista High School | Cupertino | CA |
| 42 | :50.45 | Madelyn Veith (12) | Hershey High School | Hershey | PA |
| 43 | :50.46 | Veronica Burchill (10) | Carmel High School | Carmel | IN |
| 43 | :50.46 | Siena Salvaggio (10) | Parkland High School | Allentown | PA |
| 45 | :50.47 | Breonna Barker (11) | Broken Arrow High School | Broken Arrow | OK |
| 45 | :50.47 | Kenisha Liu (10) | Ruben S. Ayala High School | Chino Hills | CA |
| 47 | :50.48 | Anna Keane (12) | Meadowdale High School | Lynnwood | WA |
| 48 | :50.49 | Kaia Grobe (11) | Chanhassen High School | Chanhassen | MN |
| 48 | :50.49 | Holly Morren (12) | Holland High School | Holland | MI |
| 50 | :50.50 | Sophie Cattermole (11) | Lemon Bay High School | Englewood | FL |
| 51 | :50.52 | Claire Rasmus (11) | The Bolles School | Jacksonville | FL |
| 52 | :50.53 | Morgan Hill (10) | Sherwood High School | Sandy Spring | MD |
| 53 | :50.55 | Laruen Rhodes (12) | Charlotte Catholic High School | Charlotte | NC |
| 53 | :50.55 | Victoria Toris (11) | Pinnacle High School | Phoenix | AZ |
| 53 | :50.55 | Rachel Wittmer (9 ) | Edina High School | Edina | MN |
| 56 | :50.59 | Sarah Kaunitz (12) | Monta Vista High School | Cupertino | CA |
| 56 | :50.59 | Tamara Santoyo (11) | William S. Hart High School | Newhall | CA |
| 58 | :50.61 | Shannon McKernan (11) | Germantown Academy | Fort Washington | PA |
| 58 | :50.61 | Asia Seidt (10) | Sacred Heart Academy | Louisville | KY |
| 60 | :50.63 | Katie Ford (12) | Mt. Lebanon High School | Pittsburgh | PA |
| 60 | :50.63 | Kirsten Vose (11) | Flintridge Sacred Heart Academy | La Canada Flintridge | CA |
| 62 | :50.64 | Niki Price (12) | Northeastern High School | Manchester | PA |
| 63 | :50.65 | Mary Ashby (11) | Campolindo High School | Moraga | CA |
| 64 | :50.66 | Bethany Galat (12) | Penn High School | Mishawaka | IN |
| 65 | :50.67 | Kasey Schmidt (11) | The Bolles School | Jacksonville | FL |
| 65 | :50.67 | Cecelia Williams (12) | Lawton Chiles High School | Tallahassee | FL |
| 67 | :50.74 | Clara Baggett (11) | Mt. Vernon High School | Mt. Vernon | IN |
| 67 | :50.74 | Sammie Hashbarger (12) | McKinney High School | McKinney | TX |
| 69 | :50.75 | Brooke Bauer (10) | Sacred Heart Academy | Louisville | KY |
| 70 | :50.76 | Emily Murphy (12) | Lima Shawnee High School | Lima | OH |
| 71 | :50.78 | Izzy Goldsmith (10) | Palo Verde High School | Las Vegas | NV |
| 72 | :50.79 | Jennifer Campbell (11) | Gunn High School | Palo Alto | CA |
| 72 | :50.79 | Lauryn Parrish (9 ) | Fishers High School | Fishers | IN |
| 74 | :50.83 | Gabrielle Bethke (12) | Gunn High School | Palo Alto | CA |
| 74 | :50.83 | Rachel Grooms (12) | Seven Lakes High School | Katy | TX |
| 76 | :50.85 | Alexandra Aitchison (11) | East Lake High School | Tarpon Springs | FL |
| 76 | :50.85 | Kate Boyer (11) | Highland Park High School | Dallas | TX |
| 76 | :50.85 | Kathryn McLaughlin (11) | Santa Margarita Catholic High School | Rancho Santa Margarita | CA |
| 79 | :50.87 | Colleen Donlin (10) | Wayzata High School | Plymouth | MN |
| 80 | :50.89 | Kelly Jacob (10) | Arrowhead High School | Hartland | WI |
| 81 | :50.92 | Emily Eastin (10) | Crean Lutheran High School | Irvine | CA |
| 82 | :50.93 | Jessica Hodgson (12) | The Bolles School | Jacksonville | FL |
| 83 | :50.95 | Heather MacDougall (10) | Crescenta Valley High School | La Crescenta | CA |
| 83 | :50.95 | Rachel Thonpson (12) | Foothill High School | Santa Ana | CA |
| 85 | :50.97 | Holly Christensen (11) | Hunterdon Central High School | Flemington | NJ |
| 85 | :50.97 | Miranda Tucker (11) | Waterford United | Waterford | MI |
| 87 | :50.99 | Kendall Smith (10) | Carmel High School | Carmel | IN |
| 88 | :51.01 | Katie Smith (10) | Pittsford Central Schools | Pittsford | NY |
| 88 | :51.01 | Abby Stone (11) | Granville High School | Granville | OH |
| 90 | :51.02 | Delaney Barnard (12) | Lawton Chiles High School | Tallahassee | FL |
| 90 | :51.02 | Morgan Bullock (10) | Zeeland High School | Zeeland | MI |
| 90 | :51.02 | Natasha Gvakharia Mgebrishvili (11) | The Bolles School | Jacksonville | FL |
| 93 | :51.04 | Megan Strickland (12) | Churchill High School | San Antonio | TX |
| 94 | :51.05 | Isabel Wyer (12) | Minnetonka High School | Minnetonka | MN |
| 95 | :51.07 | Claire Adams (10) | Carmel High School | Carmel | IN |
| 95 | :51.07 | Dani Bergeson (11) | Century High School | Bismarck | ND |
| 95 | :51.07 | Madeline Salesky (11) | Marin Academy | San Rafael | CA |
| 98 | :51.09 | Monica Sowinski (11) | Greater Latrobe High School | Latrobe | PA |
| 99 | :51.10 | Marian Yurchishin (11) | Health Careers High School | San Antonio | TX |
| 100 | :51.13 | Kaley Buchanan (9 ) | Hershey High School | Hershey | PA |
| 100 | :51.13 | Aja Grande (12) | Iolani School | Honolulu | HI |