| Place | Time | Relay Swimmers (Yrs) | School | City | State |
| 1 | 1:19.27 | Ryan Murphy (12), Joseph Schooling (11), Emiro Goossen (12), Santo Condorelli (12) | The Bolles School | Jacksonville | FL |
| 2 | 1:22.74 | Clark Smith (12), Jesse Suchomel (11), Erik Biernat (12), Zach Suter (12) | Regis Jesuit High School | Aurora | CO |
| 3 | 1:23.02 | Connor Schroyer (12), Brian Powell (10), Brian Portland (10), Will Leach (12) | Hinsdale Central High School | Hinsdale | IL |
| 4 | 1:23.10 | Jonathan DesCombes (12), Rafael Felix (10), Matthew Chalcarz (11), Spencer DeShon (12) | Capistrano Valley High School | Mission Viejo | CA |
| 5 | 1:23.37 | Austin Doss (11), Shota Nakano (12), Jeremy Bauchwitz (12), Vinny Tafuto (12) | Hershey High School | Hershey | PA |
| 6 | 1:23.39 | Blake Motal (12), Christian Garkani (12), Jack Harryman (12), Liam Karas (12) | Corona del Mar High School | Newport Beach | CA |
| 7 | 1:23.40 | Greg Brocato (9 ), Greg Rogers (12), Brendan Koch (12), Joe Maginnis (12) | LaSalle College High School | Wyndmoor | PA |
| 8 | 1:23.45 | Jacob Molacek (11), Ryan Tate (10), Sean Tate (10), Mike Bauwens (11) | Creighton Preparatory School | Omaha | NE |
| 9 | 1:23.64 | Matthew Horner (10), Thomas Donovan (12), Garrett Middleton (11), Jackson Miller (12) | Las Lomas High School | Walnut Creek | CA |
| 10 | 1:23.74 | Jack Hendricks (12), Cam Young (12), Mitchell Frey (10), Grant Johnson (12) | Saint Xavier High School | Cincinnati | OH |
| 11 | 1:23.78 | Jackson Locke (12), Michael Messner (10), Cooper Burrill (10), Aidan Burns (10) | Bellarmine College Preparatory | San Jose | CA |
| 12 | 1:23.79 | Gage Kohner (11), Sam Corona (12), Nicholas Van Zee (12), Jason McCormick (12) | Boca Raton High School | Boca Raton | FL |
| 13 | 1:23.92 | Joshua Ehrman (12), Michael Bundas (12), Stefan Koberl (12), Adam Whitener (12) | Saline Area Schools | Saline | MI |
| 14 | 1:23.94 | Stephen Watson (11), Drew Bercaw (12), Robert Tolson (12), Brian Giannetti (12) | North Canton Hoover High School | North Canton | OH |
| 15 | 1:23.99 | Josh Gill (12), Alex Duster (12), James Daughters (12), Justin Yuan (12) | Dubuque Senior High School | Dubuque | IA |
| 16 | 1:24.13 | Jake Goroshko (10), Geoffrey Boodey (12), Steve Sekula (12), Brandon McCredie (11) | Council Rock High School North | Newtown | PA |
| 17 | 1:24.16 | Mike Hill (10), Tommy McGuire (12), Justin White (12), Zach Tieke (11) | Fenwick High School | Oak Park | IL |
| 18 | 1:24.26 | Samuel Lorentz (12), Joseph Steinkamp (12), Joseph Krahulik (11), Theodore Steinkamp (12) | North Central High School | Indianapolis | IN |
| 18 | 1:24.26 | Cannon Clifton (12), Ryan Sorensen (10), Dusan Vukobrat (12), John Sanden (11) | The Woodlands High School | The Woodlands | TX |
| 20 | 1:24.29 | Travis Greenwald (12), Drake Kulick (12), Matt Krueger (12), Haden Calegan (12) | Muscatine High School | Muscatine | IA |
| 21 | 1:24.32 | Joseph Krause (11), Ryan Grady (9 ), Bradford Jones (11), Patrick Nodland (12) | Brother Rice High School | Bloomfield Hills | MI |
| 22 | 1:24.37 | Luke Kaliszak (11), Christian Selby (10), Dustin Tynes (11), Chandler Hinson (11) | The Baylor School | Chattanooga | TN |
| 23 | 1:24.43 | David Tao (12), David Schriesheim (12), Connor Fotsch (11), Reed Malone (12) | New Trier High School | Winnetka | IL |
| 24 | 1:24.56 | Ryan Stack (11), Kaikena Naone (12), Kanoa Kaleoaloha (10), Kale Ai (12) | Kamehameha Schools Kapālama High School | Honolulu | HI |
| 25 | 1:24.58 | Logan Lagesse (12), Josh Schechter (12), Ethan Pfeiffer (12), Kyle Hentschel (12) | Arapahoe High School | Centennial | CO |
| 25 | 1:24.58 | Mike McWhirter (12), Kelvin Newton (12), Bailey York (11), Adam Stacklin (12) | Waubonsie Valley High School | Aurora | IL |
| 27 | 1:24.64 | Philip Mathys (12), Josh VanKooten (12), Ryan McCracken (12), Josh Tinucci (12) | Littleton High School | Littleton | CO |
| 28 | 1:24.65 | Jared Strong (11), Michael Forbes (11), Gabriel Forbes (12), Kyle Coan (11) | Los Osos High School | Rancho Cucamonga | CA |
| 29 | 1:24.67 | Brandt Swanson (11), Jenia Foster (12), Kyle Harjes (12), Jonathan Lieberman (12) | Eden Prairie High School | Eden Prairie | MN |
| 30 | 1:24.72 | Dillon Williams (12), Brandon Carson (12), Adam Pendergraft (12), Sean Bloore (11) | Monte Vista High School | Danville | CA |
| 31 | 1:24.75 | Tyler Martin (12), Clayton Peterson (11), Clayton Young (12), Cody Tanabe (12) | San Ramon Valley High School | Danville | CA |
| 32 | 1:24.76 | Stefan Kranenburg (11), Sheldon Boboff (9 ), John Paul Naughton (11), Clark Sun (11) | Saint Ignatius College Preparatory | San Francisco | CA |
| 33 | 1:24.80 | Adam Drury (11), Steven Fishman (11), John Remmes (11), Jake Miller (10) | University High School | Normal | IL |
| 34 | 1:24.81 | Bjorn Davis (11), Brandon Cole (11), Nicholas Wargo (11), Bryce Keblish (10) | Fairfield College Preparatory School | Fairfield | CT |
| 34 | 1:24.81 | Tim Hardman (12), Julian Fraser (11), Edward Moss (10), Thomas Dillinger (10) | Greenwich High School | Greenwich | CT |
| 36 | 1:24.84 | Corey John (11), Oliver Maarse (11), Kyle Otazu (11), Josh Lo (11) | Loyola High School | Los Angeles | CA |
| 36 | 1:24.84 | Mitchell Forde (12), William Cromer (12), Ryan McMillen (12), Garrett Stephens (12) | Saint Xavier High School | Louisville | KY |
| 38 | 1:24.86 | Alex Hardwick (11), Nathan Novak (11), Tomos Williams (10), Ryan Dudzinski (10) | Upper St. Clair High School | Pittsburgh | PA |
| 39 | 1:24.87 | Daniel Bridgers (12), Zach Marshall (11), Zach Bunner (12), Jimmy Yoder (12) | Lassiter High School | Marietta | GA |
| 40 | 1:24.91 | Thomas Trace (11), Geoffrey Dickhaut (12), Maximilian Jelen (12), Joey Long (12) | Upper Arlington High School | Upper Arlington | OH |
| 41 | 1:24.99 | Cody Taylor (11), Sam Loescher (11), Matt Freudenthaler (10), Sam Parker (12) | Columbus North High School | Columbus | IN |
| 42 | 1:25.04 | Harry Sale (10), Andrew Reynolds (12), Robert Slaughter (10), Marshall Pringle (12) | Klein High School | Klein | TX |
| 43 | 1:25.06 | Tanner Anderson (12), Mate Kovacs (10), Travis Bavar (12), Seamus Lucero-Dixon (12) | Penn High School | Mishawaka | IN |
| 44 | 1:25.17 | Phillip Ugarte (11), Lucas Mestas-Nunez (12), Anthony Hauglum (10), Oliver Garnier (12) | Flour Bluff High School | Corpus Christi | TX |
| 45 | 1:25.18 | Andrew Riebel (11), Josh Elwell (12), Shane Pilkinton (10), Diogo Nogueira Ribeiro (12) | Cypress Ranch High School | Cypress | TX |
| 45 | 1:25.18 | Ali Khalafalla (11), Michael Guerci (12), Karim Elsayed (11), Mohamed Saleh (12) | Fork Union Military Academy | Fork Union | VA |
| 45 | 1:25.18 | Jeremiah Morren (12), Jonathon Maat (12), Derek Bosko (12), Thomas Rathbun (11) | Holland High School | Holland | MI |
| 48 | 1:25.21 | Zayd Othman (12), Benji Mock (12), Walker Thaning (11), Ryan Barsanti (12) | Heritage High School | Brentwood | CA |
| 49 | 1:25.22 | Spencer Adickes (11), Travis Lipscomb (12), Christopher Spears (12), Austin Frey (12) | Alamo Heights High School | San Antonio | TX |
| 49 | 1:25.22 | Mike Burke (11), Josh Kanute (12), Jonathan Thielen (12), Jack Fergus (11) | Marmion Academy | Aurora | IL |
| 51 | 1:25.25 | Gabriel Espinosa (12), Brad Dorsey (11), Ryan McCoy (11), Alex Becker (11) | Brophy College Preparatory | Phoenix | AZ |
| 52 | 1:25.26 | Len Sterle (12), Justin Ciferno (11), Jackson Morton (11), Grant Gillenwater (12) | Mayfield High School | Mayfield Village | OH |
| 52 | 1:25.26 | Andrew Liang (11), William Lee (11), Andrew Cho (9 ), Winston Wang (10) | Palo Alto High School | Palo Alto | CA |
| 54 | 1:25.28 | Brandon Boval (11), Kyle Cude (10), Luke Deloye (12), Taylor Peterson (12) | Tesoro High School | Las Flores | CA |
| 55 | 1:25.29 | Anthony Walker (12), Alex Peterson-Weber (10), Nathan Eckerle (11), Nick Menninga (12) | James Madison Memorial High School | Madison | WI |
| 55 | 1:25.29 | Alex Hillsley (12), Carter Hardy (10), Trevor Beahm (12), Jan Lazny (12) | State College Area High School | State College | PA |
| 57 | 1:25.30 | Max Phillips (12), Miles MacKenzie (11), Sebastian Harvey (12), Connor Corrigan (12) | Fairview High School | Boulder | CO |
| 58 | 1:25.31 | Sam Coffman (10), Brian Jack (12), Kyle Colley (11), Eric Fuqua (11) | Cherry Creek High School | Englewood | CO |
| 59 | 1:25.33 | James Walters (11), Matthew Payne (10), Spencer Carroll (10), Dylan Payne (12) | Mater Dei High School | Santa Ana | CA |
| 60 | 1:25.37 | Will Peterson (10), Ernest Beynars (11), Christopher Wieser (11), Keegan Shuping (11) | Jesuit High School | Carmichael | CA |
| 60 | 1:25.37 | Nathan Christian (11), Peter Simcox (11), Rayon Artis (9 ), Charlie Pophal (12) | Saint Ignatius High School | Cleveland | OH |
| 62 | 1:25.38 | Patrick Conaton (11), Richard Mannix (11), Oliver Patrouch (11), Joe Eiden (12) | Fordham Preparatory School | Bronx | NY |
| 63 | 1:25.41 | Nehemiah Mork (9 ), Benjamin Martin (12), Zachary Hoffman (10), Jackson Goethe (12) | H. H. Dow High School | Midland | MI |
| 64 | 1:25.42 | Andrew Jovanovic (12), Jack Considine (12), Christopher Kearney (9 ), Blake Morgan (12) | Loyola Academy | Wilmette | IL |
| 65 | 1:25.45 | Brian Habacivch (12), Patrick Wells (12), Spencer Davies (12), Andrew Bratton (11) | Du Pont Manual High School | Louisville | KY |
| 66 | 1:25.47 | Jacob Gonzales (12), Jules Lawrence (12), Kyle Hendricks (11), Vincent Carag (10) | Klein Collins High School | Spring | TX |
| 67 | 1:25.57 | Trevor Mylin (12), Soren Evans (11), Matt Bender (12), Scott Goddin (12) | Seminole High School | Sanford | FL |
| 68 | 1:25.59 | Jeremy Estes (12), Tore Grasso (12), Joe Gebhart (11), Gunner Braden (12) | Boulder City High School | Boulder City | NV |
| 69 | 1:25.61 | Chase Garrott (10), Coleman Phelps (12), Liam Garrott (12), Zachary Kline (12) | Frisco Wakeland High School | Frisco | TX |
| 70 | 1:25.62 | Brennan Maisch (12), Paul Ruble (12), Maxwell Merriman (12), Jonathan Zofchak (12) | Dexter High School | Dexter | MI |
| 71 | 1:25.64 | Yu-Bin Kim (11), Parker Jadwin (11), Juson Hoo (12), Michael Wen (12) | Westlake High School | Westlake Village | CA |
| 72 | 1:25.67 | Zachary Dorrego (12), Bryan Smiley (11), Alek Walton (10), Tanner Shore (10) | Santiago High School | Corona | CA |
| 73 | 1:25.69 | Sam Miseyka (11), Sebastian Piekarski (11), Klye Ujiiye (12), Jack Strauss (11) | Barrington High School | Barrington | IL |
| 74 | 1:25.72 | Justin Garner (11), Spencer Glover (12), Rustin Shoemaker (11), Edgar Febres (12) | Mountain View High School | Mesa | AZ |
| 75 | 1:25.73 | Nathan Anderson (11), Connor Saeli (12), Michael Shaben (11), Addison Williams (12) | Birmingham Seaholm High School | Birmingham | MI |
| 76 | 1:25.75 | Jay Friestad (12), Duncan Lee (9 ), Carter Constein (11), Kyle Whieldon (11) | Plano Senior High School | Plano | TX |
| 76 | 1:25.75 | Thomas Cooper (11), Daniel Whitehead (12), Chandler Lichtefeld (11), Preston Schilling (12) | Trinity High School | Louisville | KY |
| 78 | 1:25.79 | Ryan Nicholson (11), Nathan Bach (12), Francis Schickel (9 ), Will Fisher (12) | Ithaca High School | Ithaca | NY |
| 79 | 1:25.80 | Seth Wenner (12), Nick Francis (11), Zachary Snyder (9 ), Jack Brenneman (11) | Cumberland Valley High School | Mechanicsburg | PA |
| 80 | 1:25.81 | Jon Salomon (10), Tommy Cahill (12), Seamus Heneghan (11), Kevin Benson (11) | Glenbrook South High School | Glenview | IL |
| 81 | 1:25.82 | M P Salinas (12), Billy Beard (9 ), Hadid Thomas (11), Erik Dresden (11) | Malvern Preparatory School | Malvern | PA |
| 82 | 1:25.84 | Stephen Marn (9 ), Jack Mahoney (9 ), Jonathan Ekas (11), Andrew Steehler (12) | McDowell High School | Erie | PA |
| 83 | 1:25.87 | Kevin Wylder (11), Thomas Thorpe (11), Max Vigeant (9 ), Nathan Pinkney (12) | Granite Bay High School | Granite Bay | CA |
| 83 | 1:25.87 | Sebastian Lutz (10), Jamie Finnegan (10), Kamau Holston (10), Will LaCosta (12) | The Pingry School | Martinsville | NJ |
| 85 | 1:25.88 | Buzz Rehnberg (11), Brett Weicht (10), Sean Satterthwaite (12), Pierce Schultz (12) | Edina High School | Edina | MN |
| 86 | 1:25.93 | Andrew Urness (12), Kyle Bodine (12), Sam Kendall (11), Sheldon Hatlen (12) | Rosemount High School | Rosemount | MN |
| 87 | 1:25.96 | Max Irwin (12), Jack Ryan (12), Ben Calvert-Rosenberger (12), Jack Spore (12) | Bloomington High School North | Bloomington | IN |
| 88 | 1:25.99 | Austin Flager (12), Takoda Friesen (11), Jonathan Stoller (11), Austin Bernth (12) | Northridge High School | Middlebury | IN |
| 89 | 1:26.00 | Taylor Nunnery (12), TJ Bindseil (12), Alec Carnell (12), Will Shanel (11) | St. Charles East High School | St. Charles | IL |
| 90 | 1:26.01 | Seth Nabors (9 ), Ryan Perry (12), Cooper Couchman (12), Nick Alexander (12) | Clovis High School | Clovis | CA |
| 90 | 1:26.01 | Jacob Elieson (12), Grayson Magruder (11), Austin Nguyenphu (12), Taylor Willenbring (11) | Southlake Carroll High School | Southlake | TX |
| 92 | 1:26.02 | Matt Morgott (10), Jake Wasko (11), Brody Clarke (11), Nick Leshok (11) | North Farmington High School | Farmington Hills | MI |
| 92 | 1:26.02 | Robert Douglas (11), Jono Nelson (11), Kaison Ifill (10), Seth Magoon (12) | Suffield Academy | Suffield | CT |
| 94 | 1:26.04 | Nicholas Lucash (12), Logan Schul (12), Trevor Gordon (11), Hunter Mountain (12) | Coatesville Area Senior High School | Coatesville | PA |
| 94 | 1:26.04 | Reid Lazzarini (12), David Ren (9 ), Sean Elmurib (10), Taylor Ford (12) | Saint Francis High School | Mountain View | CA |
| 96 | 1:26.06 | Timothy Jones (9 ), Thomas Jones (11), James Jones (9 ), James Murphy (9 ) | Robinson Secondary School | Fairfax | VA |
| 97 | 1:26.10 | Ryan Hausler (12), Trevor Brinton (10), Philip Magorry (11), Matthew Brinton (12) | Avon Grove High School | West Grove | PA |
| 97 | 1:26.10 | Andrew Kozlovski (12), Patrick Lavelle (12), Garrison Bemis (11), Chris Powell (12) | Mill Creek High School | Hoschton | GA |
| 99 | 1:26.11 | Jason Head (9 ), Jack Brown (11), Dexter Tan (11), Alex Sajewski (12) | Keller Central High School | Keller | TX |
| 100 | 1:26.15 | Tabahn Afrik (10), Blake Kata-Carlson (12), Ben Patchin (12), Blake Wheeler (10) | Holland West Ottawa High School | Holland | MI |
| 100 | 1:26.15 | Sean Mulvin (10), Michael Kessler (12), C J Capizzi (10), Kevin Bressler (12) | Perkins High School | Sandusky | OH |