| Place | Time | Swimmer (Yr) | School | City | State |
| 1 | 4:31.38 | Katie Ledecky (10) | Stone Ridge School | Bethesda | MD |
| 2 | 4:36.41 | Leah Smith (12) | Oakland Catholic High School | Pittsburgh | PA |
| 3 | 4:39.11 | Chelsea Chenault (12) | Carondelet High School | Concord | CA |
| 4 | 4:40.97 | Danielle Valley (12) | Lakewood Ranch High School | Bradenton | FL |
| 5 | 4:41.10 | Rachel Zilinskas (12) | Germantown Academy | Fort Washington | PA |
| 6 | 4:43.38 | Leah Stevens (10) | Sacred Heart Academy | Louisville | KY |
| 7 | 4:44.47 | Ella Eastin (10) | Crean Lutheran High School | Irvine | CA |
| 8 | 4:45.19 | Brooke Lorentzen (11) | Capistrano Valley High School | Mission Viejo | CA |
| 9 | 4:45.27 | Taylor Katz (12) | Riverview High School | Sarasota | FL |
| 10 | 4:45.46 | Cece Williams (11) | Lawton Chiles High School | Tallahassee | FL |
| 11 | 4:47.17 | Ellen Berdusco (10) | Saint Stephens Episcopal School | Bradenton | FL |
| 12 | 4:47.26 | Zoe Thatcher (11) | Mason High School | Mason | OH |
| 13 | 4:47.66 | Hannah Moore (11) | Green Hope High School | Cary | NC |
| 14 | 4:47.96 | Michaela Merlihan (12) | Esperanza High School | Anaheim | CA |
| 15 | 4:48.18 | Genevieve Miller (12) | The Bolles School | Jacksonville | FL |
| 16 | 4:48.49 | Rebecca Postoll (10) | Kennesaw Mountain High School | Kennesaw | GA |
| 17 | 4:48.58 | Jenna Bauer (11) | Montgomery High School | Santa Rosa | CA |
| 17 | 4:48.58 | Eryn Eddy (10) | Thompson Valley High School | Loveland | CO |
| 19 | 4:48.95 | Sandra Soe (10) | Pioneer High School | San Jose | CA |
| 20 | 4:48.96 | Amelia Schilling (12) | Minnetonka High School | Minnetonka | MN |
| 21 | 4:49.18 | Chenoa Devine (9 ) | Davis Senior High School | Davis | CA |
| 22 | 4:49.44 | Brittany Hammond (12) | Pine Crest School | Fort Lauderdale | FL |
| 22 | 4:49.44 | Amanda Richey (11) | Boulder High School | Boulder | CO |
| 24 | 4:49.57 | Lauren Abruzzo (12) | Kent Denver School | Englewood | CO |
| 25 | 4:49.66 | Ashley Neidigh (12) | The Bolles School | Jacksonville | FL |
| 26 | 4:49.77 | Rachel Muller (12) | Brookwood High School | Snellville | GA |
| 27 | 4:49.80 | Hannah James (11) | Riverview High School | Sarasota | FL |
| 28 | 4:49.87 | Carrie Bencic (12) | Hawken School | Gates Mills | OH |
| 29 | 4:49.88 | Erin Emery (10) | Palo Verde High School | Las Vegas | NV |
| 30 | 4:50.02 | Elise Locke (12) | Presentation High School | San Jose | CA |
| 31 | 4:50.03 | Elizabeth Stinson (10) | Harpeth Hall School | Nashville | TN |
| 32 | 4:50.12 | Sarah Shimomura (10) | Archbishop Mitty High School | San Jose | CA |
| 33 | 4:50.27 | Ashley Boyles (12) | Klein Collins High School | Spring | TX |
| 34 | 4:50.44 | Lindsay Manning (12) | Oak Ridge High School | Conroe | TX |
| 35 | 4:50.53 | Kirsten Jacobsen (9 ) | Barrington High School | Barrington | IL |
| 36 | 4:50.55 | Alexandra Buscher (10) | Memorial High School | Houston | TX |
| 37 | 4:50.64 | Nika Fellows (11) | La Cueva High School | Albuquerque | NM |
| 38 | 4:50.85 | Charlotte Meyer (12) | Walt Whitman High School | Bethesda | MD |
| 39 | 4:51.07 | Moriah Simonds (9 ) | Granada High School | Livermore | CA |
| 40 | 4:51.45 | Summer Finke (10) | Countryside High School | Clearwater | FL |
| 41 | 4:51.47 | Katherine Duggan (10) | Lake Highland Preparatory School | Orlando | FL |
| 42 | 4:51.48 | Sharli Brady (11) | Randall Cooper High School | Union | KY |
| 43 | 4:51.51 | Anna Jahns (10) | Brookwood High School | Snellville | GA |
| 44 | 4:51.53 | Hanna Huston (10) | James E. Taylor High School | Katy | TX |
| 45 | 4:51.64 | Jennifer Campbell (10) | Gunn High School | Palo Alto | CA |
| 46 | 4:51.68 | Brittany Kampfer (9 ) | Mater Dei High School | Santa Ana | CA |
| 47 | 4:51.73 | Emily Mayo (12) | Arapahoe High School | Centennial | CO |
| 48 | 4:51.74 | Kaitlyn Ferrara (12) | St. Ursula Academy | Cincinnati | OH |
| 49 | 4:51.79 | Jordan Domeier (12) | Klein High School | Klein | TX |
| 50 | 4:51.83 | Katie McLaughlin (10) | Jserra Catholic High School | San Juan Capistrano | CA |
| 51 | 4:52.23 | Casey Francis (12) | Pine Crest School | Fort Lauderdale | FL |
| 52 | 4:52.24 | Morgan Dickson (12) | Libertyville High School | Libertyville | IL |
| 52 | 4:52.24 | Sydney Franzen (10) | Santa Margarita Catholic High School | Rancho Santa Margarita | CA |
| 54 | 4:52.25 | Cameron Davis (12) | Sarasota High School | Sarasota | FL |
| 55 | 4:52.27 | Molly Treble (11) | Massapequa High School | Massapequa | NY |
| 56 | 4:52.39 | Hannah Boyd (9 ) | University High School | Normal | IL |
| 57 | 4:52.47 | Paige Matherson (11) | San Ramon Valley High School | Danville | CA |
| 58 | 4:52.55 | Brittany Kahn (10) | Jserra Catholic High School | San Juan Capistrano | CA |
| 58 | 4:52.55 | Tatum Wade (9 ) | Christ Presbyterian Academy | Nashville | TN |
| 60 | 4:52.62 | Sydney Larson (9 ) | Rio Americano High School | Sacramento | CA |
| 61 | 4:52.91 | Gabbie Stecker (12) | Pleasant Valley High School | Riverdale | IA |
| 61 | 4:52.91 | Blaise Wittenauer-Lee (12) | Jesuit High School | Portland | OR |
| 63 | 4:52.92 | Kaersten Meitz (11) | Waukesha South High School | Waukesha | WI |
| 64 | 4:52.93 | Cameron McHugh (11) | Pope John XXIII High School | Katy | TX |
| 65 | 4:53.10 | Kira Zubar (11) | Eden Prairie High School | Eden Prairie | MN |
| 66 | 4:53.14 | Mallory Comerford (10) | Plainwell High School | Plainwell | MI |
| 67 | 4:53.21 | Autumn Finke (12) | Countryside High School | Clearwater | FL |
| 68 | 4:53.38 | Sydney Modeas (11) | Clarence High School | Clarence | NY |
| 69 | 4:53.49 | Brittney Walters (12) | Northridge High School | Middlebury | IN |
| 70 | 4:53.50 | Anna Quinn (11) | Thousand Oaks High School | Thousand Oaks | CA |
| 71 | 4:53.76 | Amelia Draney (11) | Desert Hills High School | St George | UT |
| 72 | 4:53.86 | Tommie Dillione (11) | Council Rock High School North | Newtown | PA |
| 73 | 4:53.94 | Sarah Nowaski (9 ) | West Hills High School | Santee | CA |
| 74 | 4:54.07 | Emily Zapinski (12) | Southlake Carroll High School | Southlake | TX |
| 75 | 4:54.08 | Gwendolyn Walter (12) | Troy High School | Fullerton | CA |
| 76 | 4:54.13 | Kirsten Brand (12) | Amador Valley High School | Pleasanton | CA |
| 77 | 4:54.34 | Kat Wickham (11) | Palm Springs High School | Palm Springs | CA |
| 78 | 4:54.39 | Emily Moser (10) | Fishers High School | Fishers | IN |
| 79 | 4:54.40 | Paige Kelly (11) | Hudson High School | Hudson | OH |
| 80 | 4:54.49 | Ashlee Korsberg (12) | Andover High School | Andover | MA |
| 81 | 4:54.50 | Erin Moe (12) | Westfield High School | Westfield | IN |
| 82 | 4:54.70 | Nicole Gautreau (12) | Glendora High School | Glendora | CA |
| 83 | 4:54.71 | Emily Erwin (11) | Germantown Academy | Fort Washington | PA |
| 84 | 4:54.74 | Mandy Barnes (10) | Tesoro High School | Las Flores | CA |
| 85 | 4:55.03 | Stephanie Marchuk (12) | New Trier High School | Winnetka | IL |
| 86 | 4:55.17 | Sammie Schurig (12) | Washburn Rural High School | Topeka | KS |
| 87 | 4:55.22 | Karli Thuen (10) | Jserra Catholic High School | San Juan Capistrano | CA |
| 88 | 4:55.43 | Rebecca Upton (11) | Southlake Carroll High School | Southlake | TX |
| 89 | 4:55.47 | Leia Bates (12) | James Madison High School | San Antonio | TX |
| 90 | 4:55.49 | Morgan Smith (10) | The Montclair Kimberley Academy | Montclair | NJ |
| 91 | 4:55.51 | Julia Campbell (12) | Chesterton High School | Chesterton | IN |
| 92 | 4:55.59 | Alecia McGillivray (12) | Flower Mound High School | Flower Mound | TX |
| 93 | 4:55.64 | Natalie Johnson (12) | Cedarburg High School | Cedarburg | WI |
| 94 | 4:55.78 | Kendall Brent (9 ) | Fort Myers High School | Fort Myers | FL |
| 95 | 4:55.82 | Sarah Dombkowski (11) | Plymouth High School | Canton | MI |
| 96 | 4:55.87 | Sydney King (11) | Granville High School | Granville | OH |
| 96 | 4:55.87 | Elizabeth Weldon (11) | Upper Arlington High School | Upper Arlington | OH |
| 98 | 4:55.98 | Jamie Skowronek (12) | Carmel High School | Carmel | IN |
| 99 | 4:56.05 | Davina Jaynes (12) | Churchill High School | San Antonio | TX |
| 99 | 4:56.05 | Ellie Thornbrue (10) | Century High School | Hillsboro | OR |